Premise: Dottie ``Doc'' McStuffins is a nurturing 6-year-old girl who cares for stuffed animals and toys in her playhouse clinic. When she puts on her stethoscope, something magical happens -- toys, dolls and stuffed animals come to life and she can communicate with them. Like any good doctor, Doc has assistants helping her at her clinic. Her stuffed animal friends who assist Doc include exceedingly proud dragon Stuffy, cuddly best friend Lambie and caring hippo nurse Hallie. Whether it's loose stitching, low batteries or a blow-up toy that has sprung a leak, Doc and her friends are there to fix up the stuffed animals and toys.
Grandma gives Doc and her toys the surprise of a lifetime by taking them to McStuffinsville, a town made up entirely of toys, and puts Doc in charge of the McStuffins Toy Hospital.
A busy day at the hospital shows the toys that they need training to help Doc; Stuffy tries to find his place at McStuffinsville.