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| Michael Stuhlbarg | Larry Gopnik |
| Richard Kind | Uncle Arthur |
| Fred Melamed | Sy Ableman |
| Sari Lennick | Judith Gopnik |
| Aaron Wolff | Danny Gopnik |
| Jessica McManus | Sarah Gopnik |
| Amy Landecker | Mrs. Samski |
| Peter Breitmayer | Mr. Brandt |
| Brent Braunschweig | Mitch Brandt |
| David Kang | Clive Park |
| Benjamin Portnoe | Danny's Reefer Buddy |
| Alan Mandell | Rabbi Marshak |
| George Wyner | Rabbi Nachtner |
| Simon Helberg | Rabbi Scott |
| Adam Arkin | Divorce Lawyer |
| Fyvush Finkel | Dybbuk |
Larry Gopnik is a physics professor at a 1960s university, but his life is coming apart at the seams. His wife is leaving him, his jobless brother has moved in, and someone is trying to sabotage his chances for tenure. Larry seeks advice from three different rabbis, but whether anyone can help him overcome his many afflictions remains to be seen.
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